Program

Preliminary program

Wednesday February 14^th
Thursday February 15^th
Friday February 16^th

Wednesday February 14^th

12:00-14:00	Registration and Posters set-up
14:00-14:15	Opening Remarks Cecília Rodrigues, Vice-Rector University of Lisbon Maria Beatriz Silva Lima, Faculty of Pharmacy, University of Lisbon, Dean João Gonçalves, Research Institute for Medicines (iMed.ULisboa), Director Twan Lammers, Controlled Release Society, President Helena Florindo, Spanish-Portuguese Local Chapter Controlled Release Society, President

SESSION 1: DELIVERY OF MACROMOLECULES

Chair: Helena F. Florindo, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Portugal
Vice-Chair: María Vivero-Lopez, University of Santiago de Compostela, Spain

14:15-14:55	Invited Lecture How has controlled drug delivery changed in the last 60 years: From in vitro design of simple structures to advanced targeted delivery of therapeutic agents for the treatment of autoimmune diseases and cancer Nicholas Peppas, UT Austin, USA
14:55-15:10	Oral presentation Extracellular Vesicles from Genetically Modified Myoblasts for Erythropoietin Protein and mRNA Delivery Zuriñe Eraña-Pérez, NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy (UPV/EHU), Vitoria-Gasteiz, Spain
15:10-15:50	Invited Lecture Technological challenges for the construction of (liposomal-)-enzyme dry powder inhalers Luísa Corvo, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Portugal
15:50-16:05	Oral presentation Hepatic-Targeted Dual Oral Vaccine Formulation for Chronic Hepatitis B: Amplifying Immune Efficacy with Glucan Particles João Panão Costa, Faculty of Pharmacy, University of Coimbra, Portugal
16:05-16:20	Flash presentations Intranasal DNA vaccine against SARS-CoV-2 Mariana Colaço, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Portugal Design of a Self-assembled Oral Delivery Carrier for Therapeutic Proteins to Treat Autoimmune Diseases Fabiola Anahi Chapa-Villarreal, McKetta Department of Chemical Engineering, University of Texas at Austin, USA Addressing the shortage of excipients approved for inhalation: In vitro and in vivo assessment of the toxicity of polysaccharides Ana Grenha, Centre for Marine Sciences, University of Algarve
16:20-16:50	Coffee-break • Posters viewing

SESSION 2: PHOSPHOLIPID RESEARCH IN DRUG DELIVERY

sponsored by Phospholipid Research Center (PRC)
Chair: María Victoria Lozano, University of Castilla-La Mancha, Spain
Vice-Chair: Catarina Leite Pereira, Institute for Research and Innovation in Health, Portugal

16:50-17:10

Invited Lecture

Introduction to the Phospholipid Research Center
Richard Wibel, Phospholipid Research Center, Germany

17:10-17:25

Oral presentation by PRC awardee

Advancing the treatment of Staphylococcus aureus with rifabutin-loaded liposomes – in vitro and in vivo studies
Manuela M. Gaspar, Research Institute for Medicines iMed.ULisboa, Faculty of Pharmacy, Lisboa, Portugal

SESSION 3; MICROENVIRONMENT, CELLULAR AND INTRACELLULAR TARGETING

Chair: María Victoria Lozano, University of Castilla-La Mancha, Spain
Vice-Chair: Catarina Leite Pereira, Institute for Research and Innovation in Health, Portugal

17:25-18:05	Invited Lecture Looking at nanomedicine one molecule at the time Lorenzo Albertazzi, Eindhoven University of Technology (TU/e), The Netherlands
18:05-18:20	Oral presentation Therapeutic contact lenses releasing dexamethasone & penetratin for enhanced drug bioavailability: in vitro and in vivo behaviour Nadia Toffoletto, Centro de Química Estrutural, Instituto Superior Técnico, University of Lisbon, Portugal
18:20-19:00	Invited Lecture Exploring combinatory and biomimetic strategies to improve lipid nanoparticles efficacy Salette Reis, Faculty of Pharmacy, University of Porto, Portugal
19:00-19:15	Oral presentation Making progress in glioblastoma using chemodynamic-lipid-iron nanoparticles Maria Mendes, Faculty of Pharmacy, University of Coimbra, Portugal

SESSION 4: PHD THESIS AWARD

Chair: Nicholas Peppas, University of Texas at Austin, USA
Vice-Chair: Mariana Bento, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Portugal

19:15-19:35

Prophylaxis and topical treatment of infections associated to hearing aids and contact lenses
María Vivero-Lopez, University of Santiago de Compostela, Spain

SESSION 5 Poster session

19:35-21:30

Welcome Reception with beverages and finger-food

Thursday February 15^th

08:30-09:00

Meet and greet with a luminary

SESSION 6: 3D SYSTEMS AND BIOPRINTING: FROM DRUG DELIVERY TO TESTING

Chair: María Jesus Vicent, Príncipe Felipe Research Center, Spain
Vice-Chair: Helena Almeida, i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

09:00-09:40	Invited Lecture P-selectin as an emerging target for cancer nanomedicine Ronit Satchi-Fainaro, Tel Aviv University, Israel
09:40-09:55	Oral presentation Targeting IBD: optimizing diffusion and cellular uptake using stimulus-sensitive nanosystems Andreia S. Barros, i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
09:55-10:35	Invited Lecture Multicellular 3D models and compartmentalized perfusable platforms for preclinical development of nanomedicines Bruno Sarmento, i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
10:35-10:50	Oral presentation Skin lesion prevention using green and innovative 3D-Printed Personalized Hydrogel Patch Angélica Esteves Lopes da Graça, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal
10:50-11:00	Flash presentations Cannabidiol and paclitaxel coloaded-lipid nanocapsules as a new strategy for glioblastoma treatment: in vitro and in vivo studies Laura Gómez Lázaro, Department of Pharmaceutics and Food Technology, Complutense University of Madrid, Spain Osteosarcoma Multicellular Spheroids Meet Microfluidics: A Tool to Screen New Therapeutical Strategies Sofia M. Costa, i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
11:00-11:30	Coffee-break • Posters viewing

SESSION 7: NEW APPROACHES FOR DRUG DELIVERY

Chair: José das Neves, Institute for Research and Innovation in Health, Portugal
Vice-Chair: Camilla Pegoraro, Príncipe Felipe Research Center, Spain

11:30-12:10	Invited Lecture Polypeptide-based Nanoconjugates as Multimodal Therapy María Jesús Vicent, Príncipe Felipe Research Center, Valencia, Spain
12:10-12:25	Oral presentation Two Promising Nanoformulations for Improving Latanoprost Effectiveness: Liposomes and Microemulsions Eye Drops Marco Brugnera, Innovation, Therapy and Pharmaceutical Development in Ophthalmology (InnOftal) Research Group, Universidad Complutense de Madrid (UCM), Spain
12:25-13:05	Invited Lecture How to empower nanomedicines for drug- and gene delivery to macrophages and the injured heart tissue? Hélder Santos, University of Groningen, The Netherlands
13:05-13:20	Oral presentation An injectable self-crosslinking hydrogel as a novel cell-drug delivery system for ocular regeneration Elena Ibeas Moreno, Department of Pharmacology, Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Santiago de Compostela, Spain
13:20-13:30	Flash presentations Cyclosporin A-loaded dissolving microneedle array patch retrieves inflammation on a contact dermatitis murine model Miguel Martínez-Navarrete, Department of Pharmaceutical Technology and Parasitology, University of Valencia, Spain Preclinical anti-tumor immune-mediated effect of selenium nanoparticles against Breast Cancer Cláudio Ferro, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal

13:30-14:30

Lunch • Posters viewing

SESSION 8: PRECISION MEDICINES AND IMMUNE MODULATION

Chair: Edorta Santos, University of the Basque Country, Spain
Vice-Chair: Rita Acúrcio, Faculty of Pharmacy, University of Lisbon, Portugal

14:30-15:10	Invited Lecture Extracellular vesicle-inspired therapies: exploring the synergy between EVs and nanoparticles Hector Peinado, Spanish National Cancer Research Centre, Spain
15:10-15:25	Oral presentation Personalized neoantigen cancer nanovaccine to guide host immune response against melanoma brain metastases Bárbara Carreira, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal
15:25-16:05	Invited Lecture Strategies to Promote Cancer Nanomedicine Clinical Translation Twan Lammers, RWTH Aachen University Clinic, Germany
16:05-16:20	Oral presentation Zwitterionic-grafted poly(beta aminoester) nanoparticles as selectively targeted antitumor mRNA vaccines Cristina Fornaguera, Institut Químic de Sarrià (IQS) – Universitat Ramon Llull (URL), Spain
16:20-16:30	Flash presentations Dissolving microneedle array containing mesoporous silica nanoparticles for allergen-specific immunotherapy Juan L. Paris, Allergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND. RICORS “Enfermedades inflamatorias”, Málaga, Spain Preparation and characterization of cannabidiol-functionalized lipid nanocapsules to selectively target the blood-brain barrier Juan Aparicio-Blanco, Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University, Madrid, Spain
16:30-17:00	Coffee break • Posters viewing

SESSION 9: TRANSLATION OF DRUG DELIVERY PRODUCTS AND TECHNOLOGIES (INDUSTRY SESSION)

Chair: António Almeida, Faculty of Pharmacy, University of Lisbon, Portugal
Vice-Chair: Cristina Fornaguera, Institut Químic de Sarrià (IQS) – Universitat Ramon Llull (URL)

17:00-18:30

Promoting personalized medicine and entrepreneurship to democratise nanotechnology for innovative therapeutics
María de la Fuente Freire , IDIS, Spain
DIVERSA Technologies SL, Spain

Gate2Brain Blood-Brain Barrier Shuttle Peptides, From Discovery to Applications
Meritxel Teixido, Gate2Brain, Spain

Harnessing Technology to improve Translational Research in Drug Delivery
José Catita, Paralab, Portugal

The alliance of Pharmaceutical Nanotechnology and Biotechnology
Maria José Alonso, Universidade de Santiago de Compostela, Spain

18:30-19:30	General Assembly of the SPLC-CRS
20:30	Gala dinner – Palace Conde d’Óbidos

Friday February 16^th

08:00-08:30

Registration

SESSION 10: ADVANCES AND COMPUTATIONAL APPROACHES IN DRUG DELIVERY

Chair: Inmaculada Conejos-Sánchez, Príncipe Felipe Research Center, Valencia, Spain
Vice-Chair: A. Sofia Barros, i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal

09:00-09:40	Invited Lecture Revolutionizing Drug Discovery and Delivery: The Power of Computational Approaches Rita Guedes, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Portugal
09:40-09:55	Oral presentation Near infrared light-activated formulation for the spatial controlled release of CRISPR-Cas9 ribonucleoprotein for brain gene editing Lino Ferreira, CNC – Centre for Neurosciences and Cell Biology, University of Coimbra, Portugal
09:55-10:10	Oral presentation Mass Spectrometry Imaging – Bridging Biology and Chemistry in the Design of Polymer-Drug Conjugates Snežana Đorđević, Polymer Therapeutics, Centro de Investigacion Principe Felipe and CIBERONC, Valencia, Spain
10:10-10:25	Flash presentations Citicoline eluting soft contact lenses for the treatment of neurodegenerative diabetic ocular diseases Diana Silva, Centro de Química Estrutural (CQE), Institute of Molecular Sciences, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Portugal Osteoclasts targeted nanoparticles to modulate resorption activity Patricia Diaz-Rodriguez, Department of Pharmacology, Pharmacy and Pharmaceutical Technology, I+D Farma Group (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Spain Gadolinium-doped Carbon Nanodots for Multi-modal imaging-guided Photothermal Therapy and Tumor Monitoring Roberta Cillari, Laboratory of Biocompatible Polymers, Department of “Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche” (STEBICEF), University of Palermo, Italy
10:25-10:55	Coffee-break • Posters viewing

SESSION 11: TARGETED DELIVERY OF THERAPEUTICS

Chair: Eliana Lima, Faculty of Pharmacy, Universidade Federal de Goiás, Brazil
Vice-Chair: Juan Luis Paris, IBIMA Plataforma BIONAND

10:55-11:35	Invited Lecture Inverted targeting: tumor cells go to the treatment Carmen Alvarez Lorenzo, Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma Group (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Spain
11:35-11:50	Oral presentation Polymeric micelles for blood-brain-barrier crossing and glioblastoma treatment Fernanda Andrade, Clinical Biochemistry, Drug Delivery and Therapy Group (CB-DDT), Vall d’Hebron Institut of Research (VHIR), Vall d’Hebron University Hospital, Vall d’Hebron Barcelona Hospital Campus, Spain
11:50-12:05	Oral presentation Semaglutide-loaded lipid nanocapsules effect on metabolic dysfunction-associated steatotic liver Inês Ladeiro Domingues, UCLouvain, Université Catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials Group, Brussels, Belgium
12:05-12:45	Invited Lecture Assessing the internalization and diffusion of nucleic acids in bacteria Nuno F. Azevedo, LEPABE, Dep of Chemical Engineering, Faculty of Engineering of the University of Porto, Portugal
12:45-13:00	Oral presentation Breaking Barriers in Brain’s Health: Liposomes against Neurodegeneration Patricia Mora-Raimundo, The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion – Israel Institute of Technology, Haifa, Israel

SESSION 12: CLOSING REMARKS AND AWARDS FOR THE BEST ORAL COMMUNICATIONS AND POSTERS

13:00-13:30

Helena Florindo, Spanish-Portuguese Local Chapter Controlled Release Society, President
New Elected Spanish-Portuguese Local Chapter Controlled Release Society, President